Beagle dog 90-day oral toxicity study of a novel coccidiostat - ethanamizuril

文献类型： 外文期刊

第一作者： Zhang, Keyu

作者： Zhang, Keyu;Zheng, Haihong;Wang, Xiaoyang;Fei, Chenzhong;Wang, Chunmei;Liu, Yingchun;Zhang, Lifang;Xue, Feiqun;Wei, Shuya;Tang, Shusheng

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关键词： Ethanamizuril; Oral subchronic toxicity; Beagle dogs; Triazine coccidiostats; Nephrotoxicity

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）

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年卷期： 2020 年 16 卷 1 期

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收录情况： SCI

摘要： BackgroundTriazine coccidiostats are widely used in chickens and turkeys for coccidiosis control. Ethanamizuril is a novel triazine compound that exhibits anticoccidial activity in poultry. This study was designed to evaluate the subchronic toxicity of ethanamizuril in beagle dogs at doses of 12, 60 or 300mg/kg/day in diet for 90days.ResultsEthanamizuril was well tolerated at low and middle dosages in beagle dogs, and no drug-related toxical effects were observaed in terms of survival, clinical observations, organs weight and damage in these dose groups. However, in high dose administration group, food consumption and histologic changes in kidneys were noticed in both sexes of beagle dog, although the renal lesions were finally resolved at the end of 4 weeks exposure of ethanamizuril.ConclusionsNo-observed-adverse-effect level (NOAEL) was considered for ethanamizuril at dose of 60mg/kg/day in Beagle dog. This result added toxicity effects of ethanamizuril to the safety database, which might guide safely using of ethanamizuril as a novel coccidiostat.

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