Molecular pathogenesis of the hyaluronic acid capsule of Pasteurella multocida

文献类型： 外文期刊

第一作者： Guan, Lijun

作者： Guan, Lijun;Xue, Yun;Yang, Jinqian;Zhao, Zhanqin;Guan, Lijun;Xue, Yun;Yang, Jinqian;Zhao, Zhanqin;Zhang, Lin

作者机构：

关键词： Pasteurella multocida; Capsule; Virulence; Molecular mimicry; Pathogenic mechanism

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

ISSN： 0882-4010

年卷期： 2020 年 149 卷

页码：

收录情况： SCI

摘要： Pasteurella multocida possesses a viscous capsule polysaccharide on the cell surface, which is a critical structural component and virulence factor. Capsular polysaccharides are structurally similar to vertebrate glycosaminoglycans, providing an immunological mechanism for bacterial molecular mimicry, resistance to phagocytosis, and immune evasion during the infection process. Based on the capsular antigen, P. multocida is divided into A, B, D, E, and F five serogroups. Previously, we systematically reported the biosynthesis and regulation mechanisms of the P. multocida capsule. In this paper, we take serogroup A capsular polysaccharide as the representative, systematically illuminating the P. multocida capsular virulence and epidemiology, molecular camouflage, adhesion and colonization, anti-phagocytosis, anti-complement system, cell invasion and signal transduction mechanism, to provide a theoretical basis for the research of molecular pathogenic mechanism of P. multocida capsule and the development of polysaccharides vaccine.

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