Systems biology approaches to study lipidomes in health and disease

文献类型： 外文期刊

第一作者： Alves, Marina Amaral

作者： Alves, Marina Amaral;Lamichhane, Santosh;Dickens, Alex;Ribeiro, Henrique Caracho;Sen, Partho;Oresic, Matej;Alves, Marina Amaral;Lamichhane, Santosh;Dickens, Alex;Ribeiro, Henrique Caracho;Sen, Partho;Oresic, Matej;McGlinchey, Aidan;Sen, Partho;Oresic, Matej;Wei, Fang;Hyotylainen, Tuulia

作者机构：

关键词： Lipidomics; Metabolomics; Systems biology; Genome-scale metabolic modeling; Disease biomarkers

期刊名称：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS （ 影响因子：4.698； 五年影响因子：6.044 ）

ISSN： 1388-1981

年卷期： 2021 年 1866 卷 2 期

页码：

收录情况： SCI

摘要： Lipids have many important biological roles, such as energy storage sources, structural components of plasma membranes and as intermediates in metabolic and signaling pathways. Lipid metabolism is under tight homeostatic control, exhibiting spatial and dynamic complexity at multiple levels. Consequently, lipid-related disturbances play important roles in the pathogenesis of most of the common diseases. Lipidomics, defined as the study of lipidomes in biological systems, has emerged as a rapidly-growing field. Due to the chemical and functional diversity of lipids, the application of a systems biology approach is essential if one is to address lipid functionality at different physiological levels. In parallel with analytical advances to measure lipids in biological matrices, the field of computational lipidomics has been rapidly advancing, enabling modeling of lipidomes in their pathway, spatial and dynamic contexts. This review focuses on recent progress in systems biology approaches to study lipids in health and disease, with specific emphasis on methodological advances and biomedical applications.

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