Genomic analysis of GBS data reveals genes associated with facial pigmentation in Xinyang blue-shelled layers

文献类型： 外文期刊

第一作者： Hou, Haobin

作者： Hou, Haobin;Wang, Xiaoliang;Cai, Xia;Yao, Junfeng;Yang, Changsuo;Hou, Haobin;Wang, Xiaoliang;Zhang, Caiyun;Tu, Yingying;Lv, Wenwei;Cai, Xia;Yao, Junfeng;Yang, Changsuo;Xu, Zhigang

作者机构：

期刊名称：ARCHIVES ANIMAL BREEDING （ 影响因子：1.528； 五年影响因子：1.723 ）

ISSN： 0003-9438

年卷期： 2020 年 63 卷 2 期

页码：

收录情况： SCI

摘要： Facial pigmentation is an important economic trait of chickens, especially for laying hens, which will affect the carcass appearance of eliminated layers. Therefore, identifying the genomic regions and exploring the function of this region that contributes to understanding the variation of skin color traits is significant for breeding. In the study, 291 pure-line Xinyang blue-shelled laying hens were selected, of which 75 were dark-faced chickens and 216 were white-faced chickens. The population was sequenced and typed by GBS genotyping technology. The obtained high-quality SNPs and pigmentation phenotypes were analyzed by a genome-wide association study (GWAS) and a FST scan. Based on the two analytical methods, we identified a same genomic region (10.70-11.60 Mb) on chromosome 20 with 68 significant SNPs (- log 10(P)>6), mapped to 10 known genes, including NPEPL1, EDN3, GNAS, C20orf85, VAPB, BMP7, TUBB1, ELMO2, DDX27, and NCOA5, which are associated with dermal hyperpigmentation.

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