文献类型： 外文期刊
第一作者： Qiao, Xin
作者： Qiao, Xin;Qu, Cheng;Luo, Qiming;Yang, Jie;Yang, Hua;Wen, Xiaodong;Qiao, Xin;Qu, Cheng;Luo, Qiming;Yang, Jie;Yang, Hua;Wen, Xiaodong;Wang, Yuanzhong
作者机构：
关键词： Rhizoma Paridis; Spectrum-effect; Bioactive ingredients; UHPLC-qMS
期刊名称：JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS （ 影响因子：3.935； 五年影响因子：3.563 ）
ISSN： 0731-7085
年卷期： 2021 年 194 卷
页码：
收录情况： SCI
摘要： Rhizoma Paridis (RP) with significant anti-tumor and haemostatic effects, has been used as the raw material of many Traditional Chinese preparations. However, its active ingredients are still unclear. The present study aimed to discover bioactive ingredients from RP based on spectrum-relationship and chemometric methods. Firstly, the saponins extract was prepared by phytochemical methods. Furthermore, UHPLC-QTOF-MS and UHPLC-qMS were incorporated to establish an efficient and sensitive method for obtaining the chemical profiles of RP. A total of 34 saponins were characterized in RP and 13 of them were assigned as common peaks in 25 batches of samples. After evaluation of the anti-tumor and haemostatic activities of samples, spectrum-effect relationships were investigated by the grey relational analysis (GRA), orthogonal projections to latent structures (OPLS) and back propagation artificial neural network (BP-ANN). These analyses showed that polyphyllin VII (P27), polyphyllin II (P30), dioscin (P31) and polyphyllin I (P33) play a role in the haemostatic effects of RP whereas polyphyllin VII (P27), dioscin (P31), polyphyllin I (P33), progenin III (P34) were assigned as candidate ingredients accounting for the anti-tumor activity of RP. The anti-tumor and haemostatic activities of these screened ingredients were subsequently verified in vitro. Collectively, the present study established the spectrum-effect relationship mode of RP and discovered the bioactive compounds of RP, which could be also used for exploration of bioactive compounds in herbal medicines, especially for trace compounds. (C) 2020 Published by Elsevier B.V.
分类号：
- 相关文献
作者其他论文 更多>>
-
Rapid determination of geographical authenticity of Gastrodia elata f. glauca using Fourier transform infrared spectroscopy and deep learning
作者：Deng, Guangmei;Li, Jieqing;Deng, Guangmei;Wang, Yuanzhong;Liu, Honggao
关键词：Gastrodia elata f. glauca; Fourier transform infrared spectroscopy; Deep learning; Data driven version of soft independent; modeling of class analogy
-
Identification and Expression of the Target Gene SLC24A2 of oar-miR-377 and Its Novel SNPs Effects on Wool Traits in Sheep
作者：Zhou, Huaqian;Yang, Hua;Fan, Wenhua;Zhao, Zongsheng;Zhou, Huaqian;Yang, Hua;Fan, Wenhua;Yang, Hanyulu;Yu, Qian;Yang, Yonglin;Zhang, Wenzhe
关键词：oar-miR-377; SNP; Wool traits; Sheep
-
The Effect of Clostridium butyricum-Derived Lipoteichoic Acid on Lipopolysaccharide-Stimulated Porcine Intestinal Epithelial Cells
作者：Chen, Qu;Ma, Lingyan;Wen, Yang;Lyu, Wentao;Yu, Minjie;Yang, Hua;Xiao, Yingping
关键词：
Clostridium butyricum ; inflammatory factors; IPEC-J2; lipopolysaccharide; lipoteichoic acid -
Sublethal and transgenerational effects of tetraniliprole on the tomato pinworm Phthorimaea (=Tuta) absoluta (Lepidoptera: Gelechiidae)
作者：Yao, Jiaqi;Wang, Yuguang;Yao, Jiaqi;Wang, Yuguang;Yao, Jiaqi;Qu, Cheng;Li, Yunyi;Luo, Chen;Wang, Ran;Guedes, Raul Narciso C.
关键词：Phthorimaea absoluta; Tetraniloprole; Transgenerational sublethal effects; Vitellogenin; Vitellogenin receptor; Antioxidant enzymes
-
CeJAZ3 suppresses longifolene accumulation in Casuarina equisetifolia, affecting the host preference of Anoplophora chinensis
作者：Yang, Hua;Jiang, Lijuan;Bao, Xiaochun;Liu, Haolan;Xu, Qianle;Li, Jian;Yang, Hua;Jiang, Lijuan;Bao, Xiaochun;Liu, Haolan;Xu, Qianle;Li, Jian;Yao, Xingliang;Su, Jun;Cai, Shouping;Fang, Yu
关键词：
Casuarina equisetifolia ;Anoplophora chinensis ; host preference; JAZ; longifolene; integrated pest management -
Phylogenetic and Comparative Genomics Study of Cephalopina titillator Based on Mitochondrial Genomes
作者：Yao, Huaibing;Yan, Yuanyuan;Li, Yang;Cui, Weidong;Zhan, Faqiang;Hou, Min;Ma, Wanpeng;Su, Zhanqiang;Yang, Jie;Zhan, Faqiang
关键词：camel nasal botfly;
Cephalopina titillator ; mitogenomes; genetic analysis -
Enhancing winter wheat plant nitrogen content prediction across different regions: Integration of UAV spectral data and transfer learning strategies
作者：Li, Zongpeng;Cheng, Qian;Zhai, Weiguang;Mao, Bohan;Li, Yafeng;Zhou, Xinguo;Chen, Zhen;Chen, Li;Yang, Jie
关键词：Gaussian process regression; Unequal-weight strategy; Plant nitrogen content; Transfer learning
