Natural Extracts from White Common Bean (Phaseolus vulgaris L.) Inhibit 3T3-L1 Adipocytes Differentiation

文献类型： 外文期刊

第一作者： Shi, Zhenxing

作者： Shi, Zhenxing;Yao, Yang;Ren, Guixing;Shi, Zhenxing;Zhang, Xin;Zhu, Yingying

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关键词： common bean; polyphenol; alpha-amylase inhibitor; non-starch polysaccharides; 3T3-L1

期刊名称：APPLIED SCIENCES-BASEL （ 影响因子：2.679； 五年影响因子：2.736 ）

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年卷期： 2021 年 11 卷 1 期

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收录情况： SCI

摘要： Background: Recent studies have shown that the consumption of common bean (Phaseolus vulgaris L.) foods plays an essential role in the prevention and treatment of obesity. Methods: In this study, different natural extracts that include common bean polyphenol-rich extract (CBP), alpha-amylase inhibitor-rich extract (alpha-AIE), and non-starch polysaccharides-rich extract (NSP) were isolated. Their effects on 3T3-L1 adipocytes differentiation were evaluated, respectively. Results: The results showed that CPB reduced the lipid content in the mature adipocytes to 79.29% (150 mu g/mL) and 35.13% (300 mu g/mL), and alpha-AIE reduced it to 90.20% (2 mg/mL) and 68.28% (4 mg/mL), while NSP exhibited an auxo-action, suggesting that both CBP and a-AIE inhibited 3T3-L1 adipocytes differentiation. Additionally, CBP significantly suppressed (p < 0.05) the mRNA expression level and the protein expression level of peroxisome proliferator-activated receptor gamma (PPAR gamma), CCAAT-enhancer-binding protein alpha (C/EBP alpha), sterol-regulatory element binding proteins 1 c (SREBP-1c), lipoprotein lipase (LPL), and fatty acid binding protein (ap2). Meanwhile, alpha-AIE only showed significant suppression effects on PPAR gamma, C/EBP alpha, and ap2 at the high dose of 4 mg/mL (p < 0.05). Conclusions: These findings indicate that CBP, from white common bean, might be the major component responsible for the inhibitory effects on adipocyte differentiation.

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