Heritable Gut Microbiome Associated with Salmonella enterica Serovar Pullorum Infection in Chickens

文献类型： 外文期刊

第一作者： Ding, Jinmei

作者： Ding, Jinmei;Zhou, Hao;Luo, Lingxiao;Xiao, Lu;Yang, Lingyu;Zheng, Yuming;Xu, Ke;He, Chuan;Han, Chengxiao;Luo, Huaixi;Qin, Chao;Akinyemi, Fisayo T.;Meng, He;Yang, Kaixuan;Gu, Caiju;Zhou, Zhenxiang;Huang, Qizhong

作者机构：

关键词： heritable; host genetic variants; gut microbiota; mGWAS; Salmonella Pullorum; chicken

期刊名称：MSYSTEMS （ 影响因子：6.496； 五年影响因子：8.236 ）

ISSN： 2379-5077

年卷期： 2021 年 6 卷 1 期

页码：

收录情况： SCI

摘要： Pullorum disease is one of the most common diarrhea-related diseases caused by Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum (S. Pullorum); it negatively affects the poultry industry. However, limited studies have explored the association between the gut microbiota and S. Pullorum infection in chickens. In the present study, we performed a microbiome comparison and a micro biome genome-wide association study (mGWAS) to investigate the association among the host genetics, the gut microbiota, and pullorum disease in chickens. We found that S. Pullorum infection in chickens could alter the abundance of 39 bacterial genera (P < 0.05). The altered structure and composition of the gut microbiota were also detected in the offspring. mGWAS results revealed host genetic variants to be prominently associated with gut microbial diversity and individual microbes. The pathogens Pelomonas and Brevundimonas, which had a high abundance in positive parent chickens and their offspring, were significantly associated with several genetic mutations in immunity-related genes, such as TGIF1, TTLL12, and CCR7. This finding explained why Pelomonas and Brevundimonas were heritable in S. Pullorum-infected chickens. The heritable gut microbes and identified genetic variants could provide references for the selection of resistant chickens and the elimination of pullorum disease. IMPORTANCE The present study investigated the association among the host genome, the gut microbiome, and S. Pullorum infection in chickens. The results suggested that the gut microbial structure is altered in S. Pullorum-infected chickens. The diversity and abundance of the gut microbiota remarkably differed between the offspring coming from S. Pullorum-positive and S. Pullorum-negative chickens. Heritable gut microbiota were detected in the offspring. Moreover, host genetic variants were associated with microbial diversity and individual gut microbes. The pathogens Pelomonas and Brevundimonas, which exhibited a high heritability in S. Pullorumpositive parents and their offspring, were associated with several genetic mutations in immunity-related genes.

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