Combined endocrine disruptive toxicity of malathion and cypermethrin to gene transcription and hormones of the HPG axis of male zebrafish (Danio rerio)

文献类型： 外文期刊

第一作者： Guo, Dongmei

作者： Guo, Dongmei;Wang, Qiang;Ma, Mengmeng;Qiu, Jing;Qian, Yongzhong;Liu, Wenping;Yao, Tingshan

作者机构：

关键词： Cypermethrin; Malathion; Adult zebrafish; Combined effect; Hypothalamic-pituitary-gonadal

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

ISSN： 0045-6535

年卷期： 2021 年 267 卷

页码：

收录情况： SCI

摘要： Cypermethrin (CYP) and malathion (MAT) have been widely used and are frequently detected in surface waters. The purpose of the present study was to investigate the endocrine disrupting toxicity of CYP, MAT, and CYP + MAT to 5-month-old male zebrafish (Danio rerio). After exposure, the hepatosomatic index (HSI) and gonadosomatic index (GSI) did not change significantly. Following exposure to the combination of 0.1 mu g/L CYP +25 mu g/L MAT, the E2 and VTG levels of male zebrafish were significantly increased compared to those after individual pesticide treatments. The molecular level of the hypothalamic-pituitary-gonadal (HPG) axis in zebrafish was studied; it was found that the expression of the estrogen-related genes, especially the vtgl gene, was significantly altered in 0.1 mu g/L CYP + 25 mu g/L MAT. Overall, our observation indicated that CYP or MAT could disturb the hormonal balance, and their combination of 0.1 mu g/L CYP +25 mu g/L MAT could significantly enhance the estrogenic effect. (C) 2020 Elsevier Ltd. All rights reserved.

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