UVR8 interacts with de novo DNA methyltransferase and suppresses DNA methylation in Arabidopsis

文献类型： 外文期刊

第一作者： Jiang, Jianjun

作者： Jiang, Jianjun;Liu, Fengquan;Jiang, Jianjun;Liu, Jie;Sanders, Dean;Qian, Shuiming;Zhong, Xuehua;Jiang, Jianjun;Liu, Jie;Sanders, Dean;Qian, Shuiming;Zhong, Xuehua;Ren, Wendan;Song, Jikui

作者机构：

期刊名称：NATURE PLANTS （ 影响因子：15.793； 五年影响因子：17.349 ）

ISSN： 2055-026X

年卷期： 2021 年 7 卷 2 期

页码：

收录情况： SCI

摘要： In Arabidopsis, the UV receptor UVR8 is functionally connected to DNA methylase DRM2. Through this interaction, UV light prevents DRM2 association with chromatin, suppressing DNA methylation and the associated transcriptional changes. DNA methylation is an important epigenetic gene regulatory mechanism conserved in eukaryotes. Emerging evidence shows DNA methylation alterations in response to environmental cues. However, the mechanism of how cells sense these signals and reprogramme the methylation landscape is poorly understood. Here, we uncovered a connection between ultraviolet B (UVB) signalling and DNA methylation involving UVB photoreceptor (UV RESISTANCE LOCUS 8 (UVR8)) and a de novo DNA methyltransferase (DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2)) in Arabidopsis. We demonstrated that UVB acts through UVR8 to inhibit DRM2-mediated DNA methylation and transcriptional de-repression. Interestingly, DNA transposons with high DNA methylation are more sensitive to UVB irradiation. Mechanistically, UVR8 interacts with and negatively regulates DRM2 by preventing its chromatin association and inhibiting the methyltransferase activity. Collectively, this study identifies UVB as a potent inhibitor of DNA methylation and provides mechanistic insights into how signalling transduction cascades intertwine with chromatin to guide genome functions.

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