Novel Hybrids of Podophyllotoxin and Coumarin Inhibit the Growth and Migration of Human Oral Squamous Carcinoma Cells

文献类型： 外文期刊

第一作者： Bai, Guohui

作者： Bai, Guohui;Zhao, Dan;Ran, Xin;Zhao, Degang;Bai, Guohui;Zhao, Dan;Ran, Xin;Zhao, Degang;Zhang, Lei;Zhang, Lei;Zhao, Degang

作者机构：

关键词： podophyllotoxin; coumarin; hybrid strategy; human oral squamous carcinoma cells; anticancer; molecular mechanism

期刊名称：FRONTIERS IN CHEMISTRY （ 影响因子：5.221； 五年影响因子：5.385 ）

ISSN： 2296-2646

年卷期： 2021 年 8 卷

页码：

收录情况： SCI

摘要： Oral squamous cell carcinoma is the most common malignancy of oral tumor. In this study, two novel hybrids of podophyllotoxin and coumarin were designed using molecular hybridization strategy and synthesized. Pharmacological evaluation showed that the potent compound 12b inhibited the proliferation of three human oral squamous carcinoma cell lines with nanomolar IC50 values, as well as displayed less toxicity on normal cells. Mechanistic studies indicated that 12b triggered HSC-2 cell apoptosis, induced cell cycle arrest, and inhibited cell migration. Moreover, 12b could disturb the microtubule network via binding into the tubulin. It was noteworthy that induction of autophagy by 12b was associated with the upregulation of Beclin1, as well as LC3-II. Furthermore, 12b significantly stimulated the AMPK pathway and restrained the AKT/mTOR pathway in HSC-2 cells. These results indicated that compound 12b was a promising candidate for further investigation.

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