The stage-specific long non-coding RNAs and mRNAs identification and analysis during early development of common carp, Cyprinus carpio

文献类型： 外文期刊

第一作者： Wang, Lanmei

作者： Wang, Lanmei;Zhu, Wenbin;Fu, Jianjun;Dong, Zaijie;Xu, Pao;Wang, Lanmei;Zhu, Wenbin;Fu, Jianjun;Dong, Zaijie;Xu, Pao

作者机构：

关键词： LncRNA; mRNA; Embryonic development; Stage-specific expression; Common carp (Cyprinus carpio)

期刊名称：GENOMICS （ 影响因子：5.736； 五年影响因子：4.939 ）

ISSN： 0888-7543

年卷期： 2021 年 113 卷 1 期

页码：

收录情况： SCI

摘要： Cyprinus carpio is considered an alternative vertebrate fish model to zebrafish. However, systemic times-series research on the lncRNAs and mRNAs during early development of C. carpio has not been reported yet. This study provides the first long non-coding RNA (lncRNA)-mRNA expression profiles during six main early development stages (2 h post-fertilization hpf, 6 hpf, 12 hpf, 20 hpf, 64 hpf and 1 day post-hatching). A total of 51,979 lncRNAs were identified. We screened the top 10 abundance lncRNAs and mRNAs and stage-specific lncRNAs and mRNAs (specificity measure SPM 0.9). We identified significant differentially expressed lncRNAs and mRNAs (|log2 (fold change)| >= 1 and false discovery rate FDR of <0.05). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis identified numerous signaling pathways. Additionally, the lncRNA-mRNA co-regulated network analysis of two lncRNAs (lncrps25 and malat1) and two mRNAs (mitf and troponin T) were investigated. Our results provide new insight into the role of lncRNAs and mRNAs, and would advance the understanding of lncRNA-mediated mechanisms in early development of fish.

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