Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264.7 macrophages

文献类型： 外文期刊

第一作者： Cao, Ji

作者： Cao, Ji;Li, Qian;Yao, Yao;Li, Longlong;Ma, Haitian;Cao, Ji;Li, Qian;Yao, Yao;Li, Longlong;Ma, Haitian;Shen, Xuehuai

作者机构：

关键词： Dehydroepiandrosterone; Lipopolysaccharide; Inflammation; Nrf2; NF-kappa B

期刊名称：MOLECULAR IMMUNOLOGY （ 影响因子：4.407； 五年影响因子：4.227 ）

ISSN： 0161-5890

年卷期： 2021 年 131 卷

页码：

收录情况： SCI

摘要： Dehydroepiandrosterone (DHEA) is the major steroid hormone in humans and animals, which can regulate the body's inflammatory responses. However, the detail mechanism of this beneficial function is still poorly understood. The present study aimed to explore the anti-inflammation effect of DHEA and its underlying molecular mechanism in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The findings showed that DHEA significantly inhibited the inflammation-related mediators production and pro-inflammatory cytokines expression level. Further research found that DHEA obviously blocked the LPS-stimulated PI3K/AKT, MAPK and NF-kappa B activation in RAW 264.7 cells. Meanwhile, DHEA enhanced the autophagy-dependent Keap1 protein degradation, subsequently activated the Nrf2 pathway to alleviate the redox imbalance and inflammatory responses. In conclusion, our data demonstrated that DHEA suppresses inflammatory responses through the activation of Nrf2 and inhibition of NF-kappa B in LPS-stimulated macrophages.

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