Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3 beta/beta-catenin signaling pathway

文献类型： 外文期刊

第一作者： Wei, Lian-Hui

作者： Wei, Lian-Hui;Dong, Yan;Sun, Yu-Feng;Mei, Xue-Song;Ma, Xue-Song;Shi, Jie;Yang, Qing-li;Ji, Yan-Ru;Zhang, Zheng-Hai;Song, Shu-Min;Sun, Xing-Rong;Sun, Hu-Nan

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关键词： anticancer; GSK3 beta signaling; hemp seed (Cannabis sativa L.); hydrolysates; ROS

期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：2.863； 五年影响因子：3.141 ）

ISSN： 2048-7177

年卷期： 2021 年 9 卷 4 期

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收录情况： SCI

摘要： Foodborne protein hydrolysates exhibit biological activity that may be therapeutic in a number of human disease settings. Hemp peptides (HP) generated by controlled hydrolysis of hemp proteins have a number of health benefits and are of pharmaceutical value. In the present study, we produce small molecular weight HP from hemp seed and investigate its anticancer properties in Hep3B human liver cancer cells. We demonstrate that HP treatment increased apoptosis, reduced cell viability, and reduced cell migration in Hep3B human liver cancer cells without affecting the normal liver cell line L02. We correlate these phenotypes with increased cellular ROS levels, upregulation of cleaved caspase 3 and Bad, and downregulation of antiapoptotic Bcl-2. HP treatment led to increased Akt and GSK-3 beta phosphorylation, with subsequent downregulation of beta-catenin, suggesting beta-catenin signaling modulation as a critical mechanism by which HP exhibits anticancer properties. Our findings suggest HP are of potential therapeutic interest for liver cancer treatment.

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