Analysis of chicken macrophage functions and gene expressions following infectious bronchitis virus M41 infection
文献类型： 外文期刊
第一作者： Sun, Xiaoqi
作者： Sun, Xiaoqi;Wang, Zheng;Shao, Changhao;Yu, Jia;Liu, Haoyun;Chen, Huijie;Huang, Xiaodan;Zhang, Ruili;Li, Guangxing;Li, Lu;Wang, Xiurong;Ren, Yudong
作者机构：
期刊名称：VETERINARY RESEARCH （ 影响因子：3.683； 五年影响因子：4.106 ）
ISSN： 0928-4249
年卷期： 2021 年 52 卷 1 期
页码：
收录情况： SCI
摘要： Infectious bronchitis virus (IBV) is a pathogenic coronavirus with high morbidity and mortality in chicken breeding. Macrophages with normal biofunctions are essential for host immune responses. In this study, the HD11 chicken macrophage cell line and chicken peripheral blood mononuclear cell-derived macrophages (PBMCs-M phi) were infected with IBV at multiplicity of infection (MOI) of 10. The dynamic changes of their biofunctions, including cell viability, pathogen elimination function, phagocytic ability, and gene expressions of related proteins/mediators in innate and acquired immunity, inflammation, autophagy and apoptosis were analyzed. Results showed that IBV infection decreased chicken macrophage viability and phagocytic ability, and increased pathogen elimination function. Moreover, IBV augmented the gene expressions of most related proteins in macrophages involved in multiple host bioprocesses, and the dynamic changes of gene expressions had a close relationship with virus replication. Among them, MHCII, Fc receptor, TLR3, IFN-alpha, CCL4, MIF, IL-1 beta, IL-6, and iNOS showed significantly higher expressions in IBV-infected cells. However, TLR7, MyD88, MDA5, IFN-gamma, MHCII, Fc receptor, MARCO, CD36, MIF, XCL1, CXCL12, TNF-alpha, iNOS, and IL-10 showed early decreased expressions. Overall, chicken macrophages play an important role in host innate and acquired immune responses to resist IBV infection, despite early damage or suppression. Moreover, the IBV-induced autophagy and apoptosis might participate in the virus-host cell interaction which is attributed to the biological process.
分类号：
- 相关文献
作者其他论文 更多>>
-
Genome-Wide Analysis of the PLATZ Gene Family in Oryza Genus: Evolution, Expression During Inflorescence Development and Stress Responses
作者：Chen, Hongwei;Ma, Xiufang;Lv, Guilan;Wang, Zheng;Wang, Lili;Yan, Bowen;Shang, Wenqi;Wang, Xianju;Ma, Zuobin;Zheng, Wenjing
关键词：
PLATZ gene family;Oryza genus; molecular evolution; expression profiling -
Prediction of soil organic carbon fractions in tropical cropland using a regional visible and near-infrared spectral library and machine learning
作者：Dai, Lingju;Wang, Zheng;Shi, Zhou;Chen, Songchao;Dai, Lingju;Chen, Songchao;Zhuo, Zhiqing;Ma, Yuxin
关键词：Particularly particulate organic carbon; Mineral-associated organic carbon; Memory-based learning; Spatial interpolation
-
Proteomic analysis to explore potential mechanism underlying pseudomale sperm defect in Cynoglossus semilaevis
作者：Li, Xihong;Li, Lu;Cui, Zhongkai;Li, Ming;Sun, Xuexue;Li, Zhijie;Chen, Zhangfan;Ding, Lanqing;Xu, Wenteng;Li, Xihong;Cui, Zhongkai;Li, Ming;Chen, Zhangfan;Xu, Wenteng;Li, Lu;Xu, Dongdong;Xu, Wenteng
关键词：Cynoglossus semilaevis; Spermatogenesis; Proteomic profile; Chaperone; UPS
-
Discrimination of superficial lymph nodes using ultrasonography and tissue metabolomics coupled with machine learning
作者：Li, Lu;Wang, Xinyue;Deng, Hongyan;Lu, Wenjuan;Zhou, Yasu;Ye, Xinhua;Li, Yong;Wang, Jie
关键词：lymph nodes; lymphoma; metastasis; ultrasonography; metabolomics
-
MEHP induced mitochondrial damage by promoting ROS production in CIK cells, leading to apoptosis, autophagy, cell cycle arrest
作者：Li, Lu;Han, Bing;Yu, Yanbo;Lin, Hongjin;Li, Wan;Liu, Yufeng;Lin, Hongjin
关键词：MEHP; ROS; Mitochondrial damage; Apoptosis; Autophagy; Cell cycle arrest
-
Insight into the changes in structural, physicochemical, and probiotic properties of yam peel polysaccharides subjected to different physical-assisted extraction methods
作者：Lu, Jinghui;Li, Dingjin;Duan, Zhenhua;Lu, Jinghui;Yu, Yuanshan;Xu, Yujuan;Li, Lu;Cheng, Lina;Peng, Jian;Chang, Hong;Lu, Jinghui
关键词：Chinese yam peel polysaccharides; Physicochemical properties; Surface morphology; Functional activity
-
A nuclear-encoded endonuclease governs the paternal transmission of mitochondria in Cucumis plants
作者：Shen, Jia;Xu, Xinyang;Wang, Zheng;Zhang, Yuejian;Shou, Weisong;Shen, Jia;Lyu, Xiaolong;Xu, Xinyang;Wang, Zheng;Zhang, Yuejian;Wang, Chenhao;Zhang, Mingfang;Shou, Weisong;Lyu, Xiaolong;Wang, Chenhao;Zhang, Mingfang;Lyu, Xiaolong;Wang, Chenhao;Zhang, Mingfang;Munaiz, Eduardo D.;Zhang, Mingfang;Havey, Michael J.
关键词：
