ID1 inhibits foot-and-mouth disease virus replication via targeting of interferon pathways

文献类型： 外文期刊

第一作者： Ren, Tingting

作者： Ren, Tingting;Chen, Haotai;Liu, Xinsheng;Wang, Yanxue;Fan, Aixia;Qi, Linlin;Pan, Li;Zhang, Yongguang;Sun, Yuefeng;Ren, Tingting;Chen, Haotai;Liu, Xinsheng;Wang, Yanxue;Fan, Aixia;Qi, Linlin;Pan, Li;Zhang, Yongguang;Sun, Yuefeng;Bai, Wenlong;Bai, Wenlong;Bai, Wenlong;Bai, Wenlong

作者机构：

关键词： deacetylation; foot‐ and‐ mouth disease virus; ID1; interferon; ubiquitination

期刊名称：FEBS JOURNAL （ 影响因子：5.542； 五年影响因子：5.5 ）

ISSN： 1742-464X

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收录情况： SCI

摘要： Inhibitor of DNA-binding 1 (ID1) protein has been studied intensively for its functions in tumorigenesis and maintenance of stem cell-like properties, but its roles in virus infection are less understood. In the present study, we have clearly shown that the foot-and-mouth disease virus (FMDV) promotes ID1 degradation via Cdh1-mediated ubiquitination to facilitate its replication. Mechanistic investigations reveal Forkhead Box O1 (FOXO1) as an ID1 partner, which suppresses interferon regulatory factors 3 expression and interferon (IFN) production. Further investigation identified that ID1 suppresses FOXO1 transcription activity through HDAC4-mediated deacetylation, promoting IFN production and antiviral immune response. These studies establish a prominent role for ID1 in suppressing FDMV replication, which may be extended to other viruses.

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