Marine Alkaloid Pityriacitrin and Its Analogues: Discovery, Structures, Synthetic Methods and Biological Properties

文献类型： 外文期刊

第一作者： Ke, Shaoyong

作者： Ke, Shaoyong;Xu, Tingting;Min, Yong;Wan, Zhongyi;Yang, Ziwen;Wang, Kaimei;Xu, Tingting;Yang, Ziwen

作者机构：

关键词： Marine alkaloid; pityriacitrin; analogues; structure; synthesis; biological properties

期刊名称：MINI-REVIEWS IN MEDICINAL CHEMISTRY （ 影响因子：3.862； 五年影响因子：3.742 ）

ISSN： 1389-5575

年卷期： 2021 年 21 卷 2 期

页码：

收录情况： SCI

摘要： Pityriacitrin is a natural marine alkaloid with a typical beta-carboline scaffold, and which has been demonstrated to exhibit diverse biological functions. The special structural features for pityriacitrin lead to the increasing research interest and the emergence of versatile derivatives, and many pityriacitrin analogues have been isolated or synthesized over the past decades. The structural diversity and evolved biological activity of these natural alkaloids can offer opportunities for the development of highly potential novel drugs with a new mechanism of action, and therefore, the aim of this brief review is to describe the discovery, synthesis, and biological properties of natural pityriacitrin and its derivatives, as well as the isolation source.

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