Effect of Clostridium on proliferating cell nuclear antigen and ghrelin in the small intestine of fattening pigs fed with deoxynivalenol

文献类型： 外文期刊

第一作者： Li, F.

作者： Li, F.;Huang, L.;Chen, H.;Yuan, X.;Wang, C.;Wang, J.

作者机构：

关键词： microbiological detoxification; blood analysis; intestinal morphology; toxic effects

期刊名称：WORLD MYCOTOXIN JOURNAL （ 影响因子：3.353； 五年影响因子：3.108 ）

ISSN： 1875-0710

年卷期： 2021 年 14 卷 1 期

页码：

收录情况： SCI

摘要： Grains and feed are severely contaminated by deoxynivalenol (DON) globally, threatening both human and animal health. Research on bio-degradation of DON, in general, is gaining attention. The aim of this research was to estimate the effect of Clostridium sp. WJ06 as a microbiological detoxification of DON based on the expression and distribution of proliferating cell nuclear antigen (PCNA) as well as ghrelin in the small intestine. A total of 24 fattening pigs were randomly divided into three groups. The control group was fed with a basic diet, the DON group was fed with DON at 5.0 mg/kg in feed, and the DON+C group was provided DON feed with Clostridium sp. WJ06. Several selected blood parameters, the intestinal morphology, and the expression and distribution of PCNA and ghrelin, were evaluated. The results proved that the selected blood parameters were altered, the intestinal villi were damaged, the epithelium was shed, as well as the expression and distribution of PCNA and ghrelin were changed by DON exposure. These toxic effects were prevented by the addition of Clostridium sp. WJ06. In short, the addition of Clostridium sp. WJ06 to the feed may eliminate the toxic effects of DON in fattening pigs. An underlying mechanism is likely modulation of the expression and distribution of PCNA and ghrelin.

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