Genome-wide association study of body size traits in Wenshang Barred chickens based on the specific-locus amplified fragment sequencing technology

文献类型： 外文期刊

第一作者： Li, Fuwei

作者： Li, Fuwei;Liu, Jie;Liu, Wei;Gao, Jinbo;Lei, Qiuxia;Han, Haixia;Li, Huimin;Cao, Dingguo;Zhou, Yan;Li, Fuwei;Liu, Jie;Liu, Wei;Gao, Jinbo;Lei, Qiuxia;Han, Haixia;Li, Huimin;Cao, Dingguo;Zhou, Yan;Li, Fuwei;Liu, Jie;Liu, Wei;Gao, Jinbo;Lei, Qiuxia;Han, Haixia;Li, Huimin;Cao, Dingguo;Zhou, Yan;Yang, Jingchao

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关键词： body size; GWAS; SLAF-seq; Wenshang Barred chicken

期刊名称：ANIMAL SCIENCE JOURNAL （ 影响因子：1.749； 五年影响因子：1.909 ）

ISSN： 1344-3941

年卷期： 2021 年 92 卷 1 期

页码：

收录情况： SCI

摘要： Chicken body size (BS) is an economically important trait, which has been assessed in many studies for genetic selection. However, previous reports detected functional chromosome mutations or regions using gene chips. The present study used the specific-locus amplified fragment sequencing (SLAF-seq) technology to perform a genome-wide association study (GWAS) of purebred Wenshang Barred chickens. A total of 250 one-day-old male chickens were assessed in this study. Body size in individual birds was measured at 56 days. SLAF-seq was used to genotype and GWAS analysis was carried out using the general linear model (GLM) of the TASSEL program. A total of 1,286,715 single-nucleotide polymorphisms (SNPs) were detected, of which 175,211 were tested as candidate SNPs for genome-wide association analysis using the TASSEL general linear model. Three SNPs markers reached genome-wide significance. Of these, chrZ:81729634, chrZ:81841715, and chrZ:81954149 at 81,729,634, 81,841,715, and 81,954,149 bp of GGA Z were significantly associated with body diagonal length at 56 days (BDL56); and tibia length at 56 days (TL56). These SNPs were close to three genes, including ZCCHC7, PAX5, and MELK. These results open new horizons for studies on BS and should promote the use of Chinese chickens, especially Wenshang Barred chickens.

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