Differential Cytokine Expression Analyses of CEFs and DEFs Infected with H6 Influenza Virus Strains Isolated from Anseriformes in Anhui Province, China

文献类型： 外文期刊

第一作者： Ge, Ye

作者： Ge, Ye;Yao, Qiucheng;Ge, Ye;Deng, Guohua;Ge, Ye;Chai, Hongliang;Hua, Yuping

作者机构：

关键词： Chicken embryo fibroblasts; Duck embryo fibroblasts; Influenza virus; Bean goose; H6 subtype; Cytokine expression; PCR

期刊名称：PAKISTAN JOURNAL OF ZOOLOGY （ 影响因子：0.831； 五年影响因子：0.768 ）

ISSN： 0030-9923

年卷期： 2021 年 53 卷 2 期

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收录情况： SCI

摘要： Wild birds, as reservoirs of viruses, play active roles in influenza virus transmission and reassortment. To further evaluate the potential infection risk of H6 AIVs from wild birds, we inoculated these viruses into A549 cells, which showed that these wild bird H6 AIVs have acquired the ability to cross interspecific barriers and have the potential to infect mammals. We analysed the level of cytokine expression in response to four H6 AIVs in CEFs and DEFs using real-time PCR. The results showed that the viruses from wild birds could induce a higher level of cytokine expression in CEFs than in DEFs. These findings suggested that H6 AIV in wild birds, especially migratory species, play an indispensable role in the spread and reassortment of AIVs and provide unknown opportunities for mutation and emergence of novel influenza viruses. Additional studies of AIVs originating from wild birds will help to determine viral adaptation and maintenance in alternative hosts.

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