Gut microbiota-mediated improvement of metabolic disorders by Qingzhuan tea in high fat diet-fed mice

文献类型： 外文期刊

第一作者： Feng, Lin

作者： Feng, Lin;Liu, Panpan;Zheng, Pengcheng;Gao, Shiwei;Gong, Ziming;Feng, Lin;Zhou, Jie;Zhang, Liang;Song, Chuankui;Yu, Yongchao;Wan, Xiaochun;Zhou, Jie

作者机构：

关键词： Qingzhuan tea; Gut microbiota; Metabolic syndrome; High-fat diet; Obesity

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN： 1756-4646

年卷期： 2021 年 78 卷

页码：

收录情况： SCI

摘要： Qingzhuan tea (QZT) is a dark tea which is widely consumed by Chinese national minority whose staple diets are high fat. It has been previously demonstrated that QZT has anti-inflammatory properties, however its preventive and therapeutic mechanism on metabolic syndromes remains unclear. Particularly, how QZT extract modulates the metabolic syndrome-related gut microbiota composition remains to be elucidated. This study aims to explore the changes in gut microbial communities mediated by a 16-week QZT extract consumption in a diet-induced obese mice model through 16S rRNA sequencing. Our results demonstrate that QZT extract can significantly prevent body weight gain, fat accumulation, and also reduce serum levels of total cholesterol and triglycerides, which is accompanied by a decrease in Firmicutes-to-Bacteroidetes ratio and relative abundance of S24-7 and Ruminococcaceae. Overall, our findings suggest QZT supplementation-induced gut microbial changes so that present benefits on mice with metabolic syndrome in high-fat diet-fed mice.

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