Synergistic effects of cinnamaldehyde and cinnamic acid in cinnamon essential oil against S. pullorum

文献类型： 外文期刊

第一作者： Huang, Zhaoxiang

作者： Huang, Zhaoxiang;Pang, Daorui;Liao, Sentai;Zou, Yuxiao;Zhou, Pengfei;Li, Erna;Wang, Weifei;Huang, Zhaoxiang

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关键词： S. pullorum; Antibacterial activity; Cinnamaldehyde; Cinnamic acid; Synergistic effect; Glycerophospholipid

期刊名称：INDUSTRIAL CROPS AND PRODUCTS （ 影响因子：5.645； 五年影响因子：5.749 ）

ISSN： 0926-6690

年卷期： 2021 年 162 卷

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收录情况： SCI

摘要： Cinnamon is an important spice crop that is widely cultivated in tropical regions. In this study, the antibacterial activities of four accessions of cinnamon essential oil (CEO) belonging to three different species (CEO1 and CEO4, Cinnamomum cassia Presl. (Lauraceae) bark; CEO2, Cinnamomum zeylanicum Blume (Lauraceae) bark; CEO3, Cinnamomum burmannii Blume (Lauraceae) bark) toward Salmonella enterica subsp. enterica serovar pullorum (S. pullorum) were evaluated by microdilution assay and kinetic analysis. The minimum inhibitory concentration (MIC) of the CEOs were all 0.31 mg/mL, and kinetic analysis suggested that the lag phase and maximum specific growth rate of bacteria were concentration dependent. Furthermore, to explore the synergistic antibacterial effects between main components and minor components, the volatile constituents of CEOs were determined by gas chromatography-mass spectrometry (GC-MS). Cinnamaldehyde (CM) (57.73 %-91.79 %) was the principal constituent in CEO1-CEO4 (p < 0.05), with CEO3 having the highest CM contents. Screening of the active minor compounds isolated from CEOs showed that cinnamic acid (CA), salicylaldehyde, alpha-pinene, o-anisaldehyde with MIC value of 0.31-2.5 mg/mL had better antibacterial activity. A synergistic effect against S. pullorum was observed when CA was combined with CM. To explore the potential synergistic mechanism, the membrane glycerophospholipid (GPL) composition of S. pullorum was characterized by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). CM, CA, and their combination regulated the levels of most phosphatidylethanolamines (PEs), phosphatidylglycerols (PGs), phosphatidic acids (PAs), and some cardiolipins (CLs).

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