Characterization and phytotoxicity of ophiobolins produced by Bipolaris setariae

文献类型： 外文期刊

第一作者： Zhao, Xing-Li

作者： Zhao, Xing-Li;Niu, Yong-Chun;Deng, Hui;Zhao, Xing-Li;Niu, Yong-Chun;Deng, Hui;Zhao, Xing-Li;Luo, Du-Qiang

作者机构：

关键词： Bipolaris; cytotoxic; herbicide; phytotoxin; sesterterpene

期刊名称：MYCOSCIENCE （ 影响因子：1.223； 五年影响因子：1.266 ）

ISSN： 1340-3540

年卷期： 2021 年 62 卷 1 期

页码：

收录情况： SCI

摘要： The Bipolaris setariae NY1 strain, isolated from a diseased green foxtail plant in Henan Province, China, showed strong pathogenicity towards green foxtail. In order to clarify the role of phytotoxic substances in the fungal pathogenicity, bioassay-directed isolation and bioactivity assays of secondary metabolites produced by the fungal strain were carried out. Five ophiobolins were obtained: 3-anhydro-ophiobolin A, 6-epi-ophiobolin A, 6-epi-ophiobolin B, 3-anhydro-6-epi-ophiobolin B and ophiobolin I. Bioassays on punctured and intact detached leaves of green foxtail indicated that 3-anhydro-ophiobolin A was the most phytotoxic, followed by 6-epi-ophiobolin A. The other three ophiobolins appeared to be inactive against green foxtail. The effects of 3-anhydro-ophiobolin A and 6-epi-ophiobolin A were synergistic. The symptoms on green foxtail caused by 3-anhydro-ophiobolin A or its mixture with 6-epi-ophiobolin A resembled those caused by the fungus. 3-Anhydro-ophiobolin A and 6-epi-ophiobolin A are likely the main pathogenic determinants of B. setariae. 6-epi-Ophiobolin A caused cytotoxicity against five kinds of human cancer cells: human colon adenocarcinoma cells (HCT-8), human liver cancer cells (Bel-7402), human gastric cancer cells (BGC-823), human lung adenocarcinoma cells (A549), and human ovarian adenocarcinoma cells (A2780). The results provide information for the development of herbicides and antitumor potential of the ophiobolin sesterterpenes.

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