Genome-wide association studies for mottled eggs in chickens using a high-density single-nucleotide polymorphism array

文献类型： 外文期刊

第一作者： Qu, L.

作者： Qu, L.;Shen, M. M.;Dou, T. C.;Ma, M.;Lu, J.;Wang, X. G.;Guo, J.;Hu, Y. P.;Li, Y. F.;Wang, K. H.;Shen, M. M.

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关键词： Egg quality; Genomic dissection; Layer hen; Quantitative trait loci; Variance explained by single-nucleotide; polymorphism

期刊名称：ANIMAL （ 影响因子：3.24； 五年影响因子：3.223 ）

ISSN： 1751-7311

年卷期： 2021 年 15 卷 1 期

页码：

收录情况： SCI

摘要： Mottled eggs in layer chickens are gaining increasing attention because of the economic impact on the egg industry caused by the reduced sale value of commodity eggs. However, the genetic architecture underlying mottled eggs is not well understood. The genetic architecture underlying the mottled egg trait was investigated using genome-wide association studies (GWAS) by high-density arrays, using a total of 407 pink eggs and 799 blue eggs from an F2 resource population generated by crossing Dongxiang Blue-shelled and White Leghorn chickens. The mottled egg score in blue eggs was found to be higher than that in pink eggs. The single-nucleotide polymorphism heritability of mottled egg at laying day and storage for 7 days was 0.18 and 0.20, respectively. Bivariate GWAS provided 29 significant loci, mainly located on GGA2, GGA3, GGA8, GGA10, GGA15, GGA17, and GGA23, affecting mottled egg on laying day. Candidate genes RIMS2, SLC25A32, RIMBP2, VPSI3B, and RGS3 were obtained for mottled eggshell by bivariate GWAS and gene annotation. Our findings provide new insights into the genetic architecture of mottled egg in hens, and demonstrate that a genomic selection method would be profitable for breeding out the mottled egg trait. (C) 2020 Published by Elsevier Inc. on behalf of The Animal Consortium.

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