The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity

文献类型： 外文期刊

第一作者： Gao, Leiqiong

作者： Gao, Leiqiong;Zhou, Jing;Wang, Lisha;Chen, Xiangyu;Yang, Yang;Pan, Zhiwei;Li, Zhirong;Tang, Jianfang;Hu, Li;Ye, Lilin;Yang, Sen;Chen, Yaokai;Li, Ren;Li, Ren;Zhao, Jing;Zhang, Guozhong;Huang, Qizhao;Liu, Pinghuang

作者机构：

期刊名称：SIGNAL TRANSDUCTION AND TARGETED THERAPY （ 影响因子：18.187； 五年影响因子：21.177 ）

ISSN： 2095-9907

年卷期： 2021 年 6 卷 1 期

页码：

收录情况： SCI

摘要： The adaptive immunity that protects patients from coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is not well characterized. In particular, the asymptomatic patients have been found to induce weak and transient SARS-CoV-2 antibody responses, but the underlying mechanisms remain unknown; meanwhile, the protective immunity that guide the recovery of these asymptomatic patients is elusive. Here, we characterized SARS-CoV-2-specific B-cell and T-cell responses in 10 asymptomatic patients and 64 patients with other disease severity (mild, n=10, moderate, n=32, severe, n=12) and found that asymptomatic or mild symptomatic patients failed to mount virus-specific germinal center (GC) B cell responses that result in robust and prolonged humoral immunity, assessed by GC response indicators including follicular helper T (T-FH) cell and memory B cell responses as well as serum CXCL13 levels. Alternatively, these patients mounted potent virus-specific T(H)1 and CD8(+) T cell responses. In sharp contrast, patients of moderate or severe disease induced vigorous virus-specific GC B cell responses and associated T-FH responses; however, the virus-specific T(H)1 and CD8(+) T cells were minimally induced in these patients. These results, therefore, uncovered the protective immunity in asymptomatic patients and also revealed the strikingly dichotomous and incomplete humoral and cellular immune responses in COVID-19 patients with different disease severity, providing important insights into rational design of effective COVID-19 vaccines.

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