Picornavirus 3C-a protease ensuring virus replication and subverting host responses

文献类型： 外文期刊

第一作者： Yi, Jiamin

作者： Yi, Jiamin;Peng, Jiangling;Yang, Wenping;Zhu, Guoqiang;Ren, Jingjing;Li, Dan;Zheng, Haixue

作者机构：

关键词： 3C protease; Picornavirus; Virus replication; Innate immunity; Pathogenesis

期刊名称：JOURNAL OF CELL SCIENCE （ 影响因子：4.573； 五年影响因子：4.903 ）

ISSN： 0021-9533

年卷期： 2021 年 134 卷 5 期

页码：

收录情况： SCI

摘要： The protease 3C is encoded by all known picornaviruses, and the structural features related to its protease andRNA-binding activities are conserved; these contribute to the cleavage of viral polyproteins and the assembly of the viral RNA replication complex during virus replication. Furthermore, 3C performs functions in the host cell through its interaction with host proteins. For instance, 3C has been shown to selectively `hijack' host factors involved in gene expression, promoting picornavirus replication, and to inactivate key factors in innate immunity signaling pathways, inhibiting the production of interferon and inflammatory cytokines. Importantly, 3C maintains virus infection by subtly subverting host cell death and modifying critical molecules in host organelles. This Review focuses on the molecular mechanisms through which 3C mediates physiological processes involved in virus-host interaction, thus highlighting the picornavirus-mediated pathogenesis caused by 3C.

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