Selective separation of the homologues of baicalin and baicalein from Scutellaria baicalensis Georgi using a recyclable ionic liquid-based liquid-liquid extraction system

文献类型： 外文期刊

第一作者： Wang, Lingqi

作者： Wang, Lingqi;Cai, Changyong;Liu, Jiajia;Cai, Changyong;Tan, Zhijian;Cai, Changyong;Tan, Zhijian

作者机构：

关键词： Ionic liquid; Liquid-liquid extraction; Homologues separation; Recyclable extractant

期刊名称：PROCESS BIOCHEMISTRY （ 影响因子：2.952； 五年影响因子：3.123 ）

ISSN： 1359-5113

年卷期： 2021 年 103 卷

页码：

收录情况： SCI

摘要： To explore convenient and efficient techniques for the extraction and separation of the active ingredients in medicinal plants is still ongoing. As a new class of molten salt, ionic liquids (ILs) are widely used in the extraction of bioactive compounds from plant resources. In this work, the IL-based biphasic system was developed for the extraction and separation of the homologues of baicalin and baicalein from Scutellaria baicalensis Georgi. The IL-water biphasic system is superior to the other organic solvents-water systems for the extraction and separation of baicalin and baicalein. The phase volume ratio of the IL-water biphasic system was studied, and the other influencing parameters of solid-liquid ratio, extraction temperature, extraction time, and ultrasonic time were optimized through the single factor experiments. The results revealed that the extraction yields were 43.3 mg/g and 14.3 mg/g for baicalin (aqueous phase) and baicalein (IL phase), respectively; and the distribution co-efficients were 23.8 and 13.7 for baicalin and baicalein, respectively under the optimized conditions. Finally, the IL can be easily recycled and reused by means of its temperature-responsive characteristic. This study provides a green and efficient method for the selective separation of the homologues in natural plant resources.

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