Floro-pyrazolo[3,4-d]pyrimidine derivative as a novel plant activator induces two-pathway immune system

文献类型： 外文期刊

第一作者： Shi, Qinjie

作者： Shi, Qinjie;Ji, Yuanyuan;Zhu, Weiping;Xu, Yufang;Qian, Xuhong;Shi, Yanxia;Li, Baoju;Zhao, Zhenjiang

作者机构：

关键词： pyrazolo[3,4-d]pyrimidine; Plant activators; Fluorine-containing; Immune system

期刊名称：PHYTOCHEMISTRY （ 影响因子：3.044； 五年影响因子：3.374 ）

ISSN： 0031-9422

年卷期： 2021 年 184 卷

页码：

收录情况： SCI

摘要： Plants are known to develop a multi-faceted innate immune system for pathogenic defense. Systemic acquired resistance (SAR) and induced systemic resistance (ISR) are the two main pathways. Many chemical inducers known as plant activators that activate innate immunity to defend against pathogens have been discovered. Currently, the exploitation of new plant activators is mainly done to develop analogs of salicylic acid as SAR-signaling molecules; however, the ISR pathway is hardly investigated for new plant activators. Based on recent studies on 1-methyl pyrazolo [3,4-d]pyrimidine bioactivity and ATP-induced resistance to biotrophic and necrotmphic pathogens, a new lead compound, 1-methyl-4-amino-pyrazolo [3,4-d]pyrimidine, was obtained as a new scaffold of plant activators for possible inducing ISR immunity system. Additionally, fluorine atom plays an important role in the design and development of new pesticides due to the unique physical chemistry effect, a series of pyrazolo [3,4-d]pyrimidine derivatives were designed and synthesized. Several compounds showed good broad-spectrum induced resistance in vivo, but there was no direct antibacterial activity in vitro. Notably, the introduction of fluorine atom at the para-position of the benzene ring greatly enhanced the induction activity of Pld both involved in SAR and ISR pathways, which implied the inducing resistance both in defending pathogens and insects.

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