Heilaohuguosus A-S from the fruits of Kadsura coccinea and their hepatoprotective activity

文献类型： 外文期刊

第一作者： Jia, Yan-Zhe

作者： Jia, Yan-Zhe;Yang, Yu-Pei;Xie, Qing-Ling;Wang, Meng-Yun;Li, Bin;Jian, Yu-Qing;Peng, Cai-Yun;Wang, Wei;Cheng, Shao-Wu;Liu, Bin;Cao, Liang

作者机构：

关键词： Kadsura coccinea (Lem.) A. C. Sm.; Schisandraceae; Heilaohu; Phytochemical; Lignans; Hepatoprotective activity; Fruit

期刊名称：PHYTOCHEMISTRY （ 影响因子：3.044； 五年影响因子：3.374 ）

ISSN： 0031-9422

年卷期： 2021 年 184 卷

页码：

收录情况： SCI

摘要： Phytochemical investigations on the fresh fruits of Kadsura coccinea (Lem.) A. C. Sm. have led to the isolation of fourteen undescribed 2,2'-cyclolignans named heilaohuguosus A-N, four undescribed aryltetrahydronaphthalene lignans, heilaohuguosus O-R and one tetrahydrofuran lignan, heilaohuguosu 5, with twenty-seven previously described lignan analogues. Their structures and absolute configurations of heilaohuguosus A S were established by spectroscopic methods including 1D and 2D-NMR techniques and CD experiments. All isolated compounds were evaluated for their hepatoprotective activity against APAP-induced toxicity in HepG 2 cells, four 2,2'-cyclolignans, heilaohuguosus A and L, tiegusanin I and kadsuphilol I showed good hepatopmtective activities against APAP toxicity in HepG 2 cells with cell survival rates of 53.5 +/- 1.7%, 55.2 +/- 1.2%, 52.5 +/- 2.4%, and 54.0 +/- 2.2% (positive control bicyclol, 52.1 +/- 1.3%) at 10 mu M, respectively.

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