Fabrication of nanostructured multi-unit vehicle for intestinal-specific delivery and controlled release of peptide

文献类型： 外文期刊

第一作者： Feng, Kun

作者： Feng, Kun;Li, Shu-Fang;Wei, Yun-Shan;Zong, Min-Hua;Wu, Hong;Hu, Teng-Gen;Hu, Teng-Gen;Han, Shuang-Yan

作者机构：

关键词： multi-unit vehicle; chitosan; high deacetylation degree; sodium alginate; intestinal-specific delivery; controlled release

期刊名称：NANOTECHNOLOGY （ 影响因子：3.551； 五年影响因子：3.392 ）

ISSN： 0957-4484

年卷期： 2021 年 32 卷 24 期

页码：

收录情况： SCI

摘要： An oral multi-unit delivery system was developed by incorporating the nanoparticle (NP) into the nanofiber mat and its efficiency for intestinal-specific delivery and controlled release of a peptide (insulin) was investigated. Initially, the influence of deacetylation degree (DD) of chitosan and ionic gelation methods on the properties of NPs was studied. High DD (95%) chitosan was attributed to higher encapsulation efficiency and stability when crosslinked with polyanion tripolyphosphate. Subsequently, the multi-unit system was fabricated using a pH-sensitive polymer (sodium alginate) as the coating layer to further encapsulate the NP. Fiber mat with an average diameter of 481 47 nm could significantly decrease the burst release of insulin in acidic condition and release most amount of insulin (>60%) in the simulated intestinal medium. Furthermore, the encapsulated peptide remained in good integrity. This multi-unit carrier provides the better-designed vehicle for intestinal-specific delivery and controlled release of the peptide.

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