A global alfalfa diversity panel reveals genomic selection signatures in Chinese varieties and genomic associations with root development

文献类型： 外文期刊

第一作者： Chen, Lin

作者： Chen, Lin;He, Fei;Long, Ruicai;Zhang, Fan;Li, Mingna;Wang, Zhen;Kang, Junmei;Yang, Qingchuan

作者机构：

关键词： alfalfa; genome-wide association studies; genomic selection; geographical origin; population structure; root development

期刊名称：JOURNAL OF INTEGRATIVE PLANT BIOLOGY （ 影响因子：7.061； 五年影响因子：6.002 ）

ISSN： 1672-9072

年卷期： 2021 年 63 卷 11 期

页码：

收录情况： SCI

摘要： Alfalfa (Medicago sativa L.) is an important forage crop worldwide. However, little is known about the effects of breeding status and different geographical populations on alfalfa improvement. Here, we sequenced 220 alfalfa core germplasms and determined that Chinese alfalfa cultivars form an independent group, as evidenced by comparisons of F-ST values between different subgroups, suggesting that geographical origin plays an important role in group differentiation. By tracing the influence of geographical regions on the genetic diversity of alfalfa varieties in China, we identified 350 common candidate genetic regions and 686 genes under selection. We also defined 165 loci associated with 24 important traits from genome-wide association studies. Of those, 17 genomic regions closely associated with a given phenotype were under selection, with the underlying haplotypes showing significant differences between subgroups of distinct geographical origins. Based on results from expression analysis and association mapping, we propose that 6-phosphogluconolactonase (MsPGL) and a gene encoding a protein with NHL domains (MsNHL) are critical candidate genes for root growth. In conclusion, our results provide valuable information for alfalfa improvement via molecular breeding.

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