Pseudorabies virus UL24 antagonizes OASL-mediated antiviral effect

文献类型： 外文期刊

第一作者： Chen, Xiaoyong

作者： Chen, Xiaoyong;Kong, Ning;Xu, Jingjing;Wang, Juan;Zhang, Mingliang;Ruan, Keyue;Li, Liwei;Zhang, Yujiao;Zheng, Hao;Tong, Wu;Li, Guoxin;Shan, Tongling;Tong, Guangzhi;Kong, Ning;Li, Liwei;Zheng, Hao;Tong, Wu;Li, Guoxin;Shan, Tongling;Tong, Guangzhi

作者机构：

关键词： OASL; Pseudorabies virus; UL24; RIG-I

期刊名称：VIRUS RESEARCH （ 影响因子：2.934； 五年影响因子：2.775 ）

ISSN： 0168-1702

年卷期： 2021 年 295 卷

页码：

收录情况： SCI

摘要： Oligoadenylate synthetases-like (OASL) protein exerts various effects on DNA and RNA viruses by inhibiting cGAS-mediated IFN production and by enhancing RIG-I-mediated IFN induction, respectively. In this study, we aimed to examine the role of OASL in pseudorabies virus (PRV) proliferation and investigate the function of the PRV UL24 protein in cellular innate immunity. We found that OASL regulates PRV proliferation by enhancing RIG-I signaling. PRV infection decreased the expression of OASL at both the mRNA and protein levels in PK15 and HeLa cells. OASL expression suppressed the proliferation of PRV in a RIG-I-dependent manner and boosted RIG-I-mediated IFN expression as well as IFN-stimulated gene (ISG) induction. In contrast, knockdown of OASL enhanced PRV proliferation and reduced RIG-I signaling. However, the PRV UL24 protein was found to impair RIG-I signaling, thus inhibiting transcription of IFN and ISGs. In addition, the UL24 protein reduced RIG-I induced expression of endogenous OASL in an IRF3-dependent manner, thereby antagonizing the OASL antiviral effect. Taken together, our findings characterize the role of OASL in PRV proliferation and provide new insights into the role of UL24 in PRV pathogenesis.

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