Genomic characterization and phylogenetic analysis of a new canine picornavirus variant in the mainland of China

文献类型： 外文期刊

第一作者： Li, Chuanfeng

作者： Li, Chuanfeng;Li, Yeqiu;Li, Hang;Chen, Zongyan;Zhou, Jiewen;Liu, Guangqing;Li, Yeqiu;Wang, Yong

作者机构：

关键词： Canine picornavirus (CanPV); Genomic characterization; Phylogenetic analysis; Mutation

期刊名称：VIRUS RESEARCH （ 影响因子：2.934； 五年影响因子：2.775 ）

ISSN： 0168-1702

年卷期： 2021 年 296 卷

页码：

收录情况： SCI

摘要： A new canine picornavirus (CanPV) variant, designated as dog/SH1901/CHN/2019, was detected in a pool of various canine fecal samples in the mainland of China using a viral metagenomic analysis, and its nearly com-plete genome sequence was determined and analyzed. Sequence analyses revealed that it had a standard picornavirus genome organization, a type I internal ribosome entry site (IRES) in the 5?UTR. However, dog/ SH1901/CHN/2019 has generated a serial of unique aa mutations and 7aa insertion when compared with the closely related CanPVs. Phylogenetic analysis and pairwise sequence comparisons based on the P1, 2C, 3C, and 3D protein sequences showed that dog/SH1901/ CHN/2019 was closely related to CanPV strains 244 F, 325 F and 6D, which clustered into an independent evolutionary clade and distantly related to CanPV strain A128thr of the genus Mischivirus, which indicated the unclassified CanPV strains may belong to a novel species or genus in the family Picornaviridae. This study extends our knowledge on the evolution and genetic diversity of CanPVs.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序