Hydrolysis Kinetics of a Novel 3,4-Dichloroisothiazole Plant-Activator Candidate LY5-24-2 by UPLC-Q-TOF

文献类型： 外文期刊

第一作者： Song, Shuangyu

作者： Song, Shuangyu;Han, Lijun;Bi, Yingying;Qin, Fayi;Qiao, Chengkui;Xie, Hanzhong;Wu, Qifan;Li, Yuedong;Fan, Zhijin

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关键词： Hydrolysis; Plant activator; UPLC-Q-TOF; Non-target analysis

期刊名称：BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY （ 影响因子：1.657； 五年影响因子：1.707 ）

ISSN： 0007-4861

年卷期：

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收录情况： SCI

摘要： Hydrolysis characteristics of a novel 3,4-dichloroisothiazole based fungicide with activating plant defense responses as a candidate plant-activator LY5-24-2 were investigated under different conditions (pH and temperature) using ultra-performance liquid chromatography (UPLC) and quadrupole Time-of-Flight (Q-TOF). The hydrolysis case complied with the first-order kinetic model, with half-lives ranging from 4.8 h to 3.2 days at pH 4, 7, 9 and temperature at 25 and 50celcius. One of the hydrolysis metabolite 3,4-dichloroisothiazole-5-carboxylic acid (metabolite 1, M1) was determined and quantified using authentic standard. The other hydrolysate 3-chloro-5-(trifluoromethyl) pyridin-2-amine (metabolite 2, M2) was determined and identified according to accurate mass information, fragmentation patterns and principle component analysis (PCA). By utilizing high-resolution mass spectrometry and multivariate statistical analysis, hydrolysis dynamic of the metabolites was characterized and figured out. This research provided a non-target screening method to analyze hydrolysis metabolites of a new plant-activator and to find its degradation products in aqueous solution.

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