Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy
文献类型： 外文期刊
第一作者： Li, Hong
作者： Li, Hong;Liu, Tingli;Yang, Yongchun;Song, Houhui;Zheng, Yadong;Cho, William C.;Flynn, Robin J.;Flynn, Robin J.;Harandi, Majid Fasihi;Song, Houhui;Zheng, Yadong;Luo, Xuenong
作者机构：
关键词： Diagnosis; Hepatic stellate cell; Liver fibrosis; miRNA; Therapy
期刊名称：GENES & DISEASES （ 影响因子：6.8； 五年影响因子：7.8 ）
ISSN： 2352-4820
年卷期： 2023 年 10 卷 4 期
页码：
收录情况： SCI
摘要： microRNAs (miRNAs) are a class of non-coding functional small RNA composed of 21-23 nucleotides, having multiple associations with liver fibrosis. Fibrosis-associated miRNAs are roughly classified into pro-fibrosis or anti-fibrosis types. The former is capable of activating hepatic stellate cells (HSCs) by modulating pro-fibrotic signaling pathways, mainly including TGF-I3/SMAD, WNT/I3-catenin, and Hedgehog; the latter is responsible for maintenance of the quiescent phenotype of normal HSCs, phenotypic reversion of activated HSCs (aHSCs),
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