A Self-Catabolic Multifunctional DNAzyme Nanosponge for Programmable Drug Delivery and Efficient Gene Silencing

文献类型： 外文期刊

第一作者： Wang, Jing

作者： Wang, Jing;Yu, Shanshan;Wu, Qiong;Gong, Xue;He, Shizhen;Shang, Jinhua;Liu, Xiaoqing;Wang, Fuan;Wang, Jing

作者机构：

关键词： aptamer; DNAzyme; drug delivery; gene silencing; rolling circle amplification

期刊名称：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION （ 影响因子：12.959； 五年影响因子：12.659 ）

ISSN： 1433-7851

年卷期： 2021 年 60 卷 19 期

页码：

收录情况： SCI

摘要： DNAzyme-based gene therapy holds immense prospects for effectively treating severe diseases, yet is constrained with inefficient delivery and unconditional activation. Herein, we designed a bioinspired self-catabolic DNA nanocapsule for sustaining tumor-specific cascade activation of therapeutic DNAzyme. The exquisite DNAzyme was temporarily masked by the self-excising DNAzyme in the hierarchical rolling circle replication (RCR) nanostructures, thus stayed in an inactive state in physiological fluids. Through the multivalent tumor-anchoring aptamer strands, the RCR nanocapsule was specifically accumulated in cancer cells and was sequentially activated for motivating the ultimate DNAzyme-mediated gene silencing via the intelligent stimuli-responsive cascade DNAzyme activation. By virtue of the programmable RCR assembly strategy, our compact DNAzyme nanoplatform shows great promise for developing versatile smart gene therapeutics and personalized nanomedicines.

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