Cyst(e)ine fortification in low crude protein diet improves growth performance of broilers by modulating serum metabolite profile

文献类型： 外文期刊

第一作者： Wang, Wei-wei

作者： Wang, Wei-wei;Feng, Qian-qian;Wang, Jing;Wu, Shu-geng;Qi, Guang-hai;Zhang, Hai-jun

作者机构：

关键词： Cyst(e)ine; Broiler; Growth performance; Metabolomics; Metabolic pathway

期刊名称：JOURNAL OF PROTEOMICS （ 影响因子：3.509； 五年影响因子：3.637 ）

ISSN： 1874-3919

年卷期： 2021 年 238 卷

页码：

收录情况： SCI

摘要： This study was aimed to explore the metabolomical mechanisms for the potentially ameliorative effect of cyst(e) ine (Cys) fortification on growth performance of broilers fed low crude protein (CP) diet. A total of 432 1-d-old broilers were randomly divided into 6 groups, each of which received one of the following diets: normal-CP diet (positive control, PC), low-CP diet (negative control, NC), NC diet fortified with 0.05%, 0.1%, 0.15% or 0.2% of Cys. Samples were collected on d 42. Results showed that increasing Cys fortification quadratically elevated (P < 0.05) the accumulative growth performance and leg muscle yield of broilers fed NC diet, with 0.1% being the optimal dose. Thus, samples from PC, NC and NC plus 0.1% Cys (NCC) groups were selected for further analysis. Both dietary CP reduction and fortification of 0.1% Cys in NC diet caused complex changes (P < 0.05) in serum amino acids and some other metabolites primarily involved in lipid metabolism. Multiple lipogenesis-related pathways were regulated (P < 0.05) following Cys fortification in NC diet, which could at least partially interpret the benefit of Cys fortification in NC diet on broiler performance. In conclusion, fortifying low-CP diet with 0.1% Cys promoted the growth performance of broilers probably through modulating serum metabolite profile.

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