Tachykinin signaling inhibits task-specific behavioral responsiveness in honeybee workers

文献类型： 外文期刊

第一作者： Han, Bin

作者： Han, Bin;Wei, Qiaohong;Wu, Fan;Hu, Han;Ma, Chuan;Meng, Lifeng;Zhang, Xufeng;Feng, Mao;Fang, Yu;Li, Jianke;Han, Bin;Rueppell, Olav;Wu, Fan;Zhang, Xufeng;Rueppell, Olav

作者机构：

期刊名称：ELIFE （ 影响因子：7.08； 五年影响因子：8.175 ）

ISSN： 2050-084X

年卷期： 2021 年 10 卷

页码：

收录情况： SCI

摘要： Behavioral specialization is key to the success of social insects and leads to division of labor among colony members. Response thresholds to task-specific stimuli are thought to proximally regulate behavioral specialization, but their neurobiological regulation is complex and not well understood. Here, we show that response thresholds to task-relevant stimuli correspond to the specialization of three behavioral phenotypes of honeybee workers in the well-studied and important Apis mellifera and Apis cerana. Quantitative neuropeptidome comparisons suggest two tachykinin-related peptides (TRP2 and TRP3) as candidates for the modification of these response thresholds. Based on our characterization of their receptor binding and downstream signaling, we confirm a functional role of tachykinin signaling in regulating specific responsiveness of honeybee workers: TRP2 injection and RNAi-mediated downregulation cause consistent, opposite effects on responsiveness to task-specific stimuli of each behaviorally specialized phenotype but not to stimuli that are unrelated to their tasks. Thus, our study demonstrates that TRP signaling regulates the degree of task-specific responsiveness of specialized honeybee workers and may control the context specificity of behavior in animals more generally.

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