AIEgens enabled ultrasensitive point-of-care test for multiple targets of food safety: Aflatoxin B-1 and cyclopiazonic acid as an example

文献类型： 外文期刊

第一作者： Hu, Xiaofeng

作者： Hu, Xiaofeng;Wang, Du;Jiang, Jun;Chen, Xiaomei;Zhang, Zhaowei;Li, Peiwu;Zhang, Pengfei;Liu, Yong;Tang, Ben Zhong

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关键词： Aggregation-induced emission; Lateral flow; Point-of-care test; Cyclopiazonic acid; Food safety

期刊名称：BIOSENSORS & BIOELECTRONICS （ 影响因子：10.257； 五年影响因子：8.669 ）

ISSN： 0956-5663

年卷期： 2021 年 182 卷

页码：

收录情况： SCI

摘要： Food safety is currently a significant issue for human life and health. Various fluorescent nanomaterials have been applied in the point-of-care test (POCT) for food safety as labeling materials. However, previous fluorescent nanomaterials can cause aggregation-caused quenching (ACQ), thus reducing the detection sensitivity. Conversely, aggregation-induced emission luminogens (AIEgens) are promising candidates for POCT in the food safety field because they can enhance detection sensitivity and throughput. Mycotoxins, such as aflatoxin B1 (AFB1) and cyclopiazonic acid (CPA), are a primary threat to human life and health and a significant food safety issue, and their on-site detection from farm to table is needed. Herein, an ultrasensitive point-of-care test was developed based on TPE-Br, a blue-emissive tetraphenylethylene derivative AIEgen. Under optimal conditions, this AIEgen-based lateral-flow biosensor (ALFB) allowed for a rapid response of 8 min toward AFB1 and CPA detection, with considerable sensitivities of 0.003 and 0.01 ng/mL in peanut matrices, respectively. In peanut matrices, the recoveries were 90.3%?110.0% for both mycotoxins, with relative standard deviations (RSDs) below 6%. The ALFB was further validated via UPLC-MS/MS using spiked peanut samples. AIEgens open an avenue for on-site, ultrasensitive, high-throughput detection methods and can be extensively used in point-ofcare tests in food safety.

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