Influence of triacylglycerol on the physical stability and digestion fate of triacylglycerol-bergamot mixed-oil emulsions with nobiletin

文献类型： 外文期刊

第一作者： Wei, Rujun

作者： Wei, Rujun;Zhao, Shaojie;Feng, Liping;Tian, Guifang;Zhao, Chengying;An, Qing;Zheng, Jinkai;Song, Mingyue

作者机构：

关键词： Mixed oil; Emulsion; Stability; Digestion; Nobiletin bioavailability

期刊名称：LWT-FOOD SCIENCE AND TECHNOLOGY （ 影响因子：4.006； 五年影响因子：4.385 ）

ISSN： 0023-6438

年卷期： 2021 年 144 卷

页码：

收录情况： SCI

摘要： Nobiletin is a citrus flavonoid with poor water solubility, which limits its application. To investigate the effects of emulsions on the bioavailability of nobiletin, long-chain triglycerides (LCT, i.e., corn oil) and medium-chain triglycerides (MCT) were used in combination with bergamot oil at different mixing ratios (i.e., 1:0, 3:1, 1:1, 1:3, and 0:1) as the oil phase to produce nobiletin-encapsulating emulsions by high-pressure homogenization. The emulsion stability, digestion fate, and bioavailability of nobiletin were systematically investigated. The results showed that triacylglycerol-bergamot oil at the ratio of 1:3 was the most stable. The hydrolysis rate of triacylglycerol-bergamot oil emulsions increased with increasing triacylglycerol: bergamot oil ratio. The total bioavailability of nobiletin in corn oil-bergamot oil emulsions was higher than that of pure bergamot oil and MCT-bergamot oil emulsions during in vitro digestion, due to the higher hydrolysis rate of corn oil-bergamot oil and greater solubilization capacity of micelles formed by bile salts and long-chain fatty acids (LCFAs) from corn oil. Nobiletin bioavailability was highest in the 3:1 corn oil: bergamot oil emulsion. This simulated digestion study may be useful for designing emulsion-based delivery systems to control the bioavailability of hydrophobic nutrients.

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