Clinical trials with plants in diabetes mellitus therapy: a systematic review

文献类型： 外文期刊

第一作者： Marmitt, Diorge Jonatas

作者： Marmitt, Diorge Jonatas;Goettert, Marcia Ines;Shahrajabian, Mohamad Hesam;Rempel, Claudete

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关键词： Type 2 diabetes mellitus; plants; compounds; clinical trials; therapeutic effects

期刊名称：EXPERT REVIEW OF CLINICAL PHARMACOLOGY （ 影响因子：3.481； 五年影响因子：2.942 ）

ISSN： 1751-2433

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收录情况： SCI

摘要： Introduction The chronic metabolic disorder diabetes mellitus is a fast-growing global problem with huge social, health, and economic consequences, having one of the highest morbidities and mortality rates. Prolonged use of many available medications can produce undesirable side effects. Thus, plants appear as an important source of bioactive resources for the discovery of new treatments for diabetes. Areas covered In this sense, this systematic review focused on clinical trials involving plants of National List of Medicinal Plants of Interest to the Unified Health System (RENISUS) (or compounds) with antidiabetic properties. We analyzed indexed studies in PubMed following the reporting guidelines of PRISMA. Expert Opinion Of the 51 clinical trials found, Curcuma longa, Glycine max, Zingiber officinale, Punica granatum, Aloe vera, Momordica charantia are the species with the greatest amount of clinical trials and the attenuation of insulin resistance, decreased fasting blood glucose and glycosylated hemoglobin levels are some of the main mechanisms by which these plants exert hypoglycemic effects. Thus, we speculate that the Clinical Pharmacology should explore the field of plant-based compounds that will keep concentrating the attention of researchers, and therefore, we gathered studies in advanced stages that highlight the role of plants in the diabetes therapy.

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