Genome-Wide Analyses Reveal Genetic Convergence of Prolificacy between Goats and Sheep

文献类型： 外文期刊

第一作者： Tao, Lin

作者： Tao, Lin;He, Xiaoyun;Liu, Yufang;Chu, Mingxing;Jiang, Yanting;Ouyang, Yina;Hong, Qionghua;Liu, Yufang;Shen, Yezhen

作者机构：

关键词： litter size; genetic convergence; genome; RNA-seq; sheep; goats

期刊名称：GENES （ 影响因子：3.759； 五年影响因子：3.822 ）

ISSN：

年卷期： 2021 年 12 卷 4 期

页码：

收录情况： SCI

摘要： The litter size of domestic goats and sheep is an economically important trait that shows variation within breeds. Strenuous efforts have been made to understand the genetic mechanisms underlying prolificacy in goats and sheep. However, there has been a paucity of research on the genetic convergence of prolificacy between goats and sheep, which likely arose because of similar natural and artificial selection forces. Here, we performed comparative genomic and transcriptomic analyses to identify the genetic convergence of prolificacy between goats and sheep. By combining genomic and transcriptomic data for the first time, we identified this genetic convergence in (1) positively selected genes (CHST11 and SDCCAG8), (2) differentially expressed genes (SERPINA14, RSAD2, and PPIG at follicular phase, and IGF1, GPRIN3, LIPG, SLC7A11, and CHST15 at luteal phase), and (3) biological pathways (genomic level: osteoclast differentiation, ErbB signaling pathway, and relaxin signaling pathway; transcriptomic level: the regulation of viral genome replication at follicular phase, and protein kinase B signaling and antigen processing and presentation at luteal phase). These results indicated the potential physiological convergence and enhanced our understanding of the overlapping genetic makeup underlying litter size in goats and sheep.

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