Antibacterial p-Terphenyl with a Rare 2,2 '-Bithiazole Substructure and Related Compounds Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086
文献类型： 外文期刊
第一作者： Chang, Yimin
作者： Chang, Yimin;Che, Qian;Xing, Li;Ma, Chuanteng;Han, Yaxin;Zhu, Tianjiao;Zhang, Guojian;Li, Dehai;Pfeifer, Blaine A.;Peng, Jixing;Zhang, Guojian;Li, Dehai
作者机构：
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：3.779； 五年影响因子：3.989 ）
ISSN： 0163-3864
年卷期： 2021 年 84 卷 4 期
页码：
收录情况： SCI
摘要： Assisted by MS/MS-based molecular networking and X-ray diffraction analysis, five new p-terphenyl derivatives, namely, nocarterphenyls D-H (1-5), were obtained and characterized from the cultures of the marine sediment-derived actinomycete Nocardiopsis sp. HDN154086. The skeleton of nocarterphenyl D (1) was defined to possess a rare 2,2'-bithiazole scaffold, naturally occurring for the first time, and nocarterphenyls E-H (2-5) are p-terphenylquinones with unusual thioether linked fatty acid methyl ester substitutions. Compound 1 showed promising activity against multiple bacteria with MIC values ranging from 1.5 to 6.2 mu M, and 2 exhibited notable antibacterial activity against MRSA which surpassed the positive control ciprofloxacin.
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