Prodigiosin of Serratia marcescens ZPG19 Alters the Gut Microbiota Composition of Kunming Mice

文献类型： 外文期刊

第一作者： Li, Xue

作者： Li, Xue;Tan, Xinfeng;Chen, Qingshuang;Zhang, Jing;Zhang, Jie;Jia, Baolei;Zhu, Xiaoling

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关键词： gut microbiota; Kunming mice; pathologic visceral changes; prodigiosin; Serratia marcescens

期刊名称：MOLECULES （ 影响因子：3.267； 五年影响因子：3.589 ）

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年卷期： 2021 年 26 卷 8 期

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收录情况： SCI

摘要： Prodigiosin is a red pigment produced by Serratia marcescens with anticancer, antimalarial, and antibacterial effects. In this study, we extracted and identified a red pigment from a culture of S. marcescens strain ZPG19 and investigated its effect on the growth performance and intestinal microbiota of Kunming mice. High-performance liquid chromatography/mass spectrometry revealed that the pigment had a mass-to-charge ratio (m/z) of 324.2160, and thus it was identified as prodigiosin. To investigate the effect of prodigiosin on the intestinal microbiota, mice (n = 5) were administered 150 mu g/kg/d prodigiosin (crude extract, 95% purity) via the drinking water for 18 days. Administration of prodigiosin did not cause toxicity in mice. High-throughput sequencing analysis revealed that prodigiosin altered the cecum microbiota abundance and diversity; the relative abundance of Desulfovibrio significantly decreased, whereas Lactobacillus reuteri significantly increased. This finding indicates that oral administration of prodigiosin has a beneficial effect on the intestinal microbiota of mice. As prodigiosin is non-toxic to mouse internal organs and improves the mouse intestinal microbiota, we suggest that it is a promising candidate drug to treat intestinal inflammation.

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