Determination of ligustrazine in rat serum by polymer monolithic micro-extraction combined with ultra high performance liquid chromatography-tandem mass spectrometry

文献类型： 外文期刊

第一作者： Sun, Danling

作者： Sun, Danling;Peng, Xitian;Peng, Maomin;Zhang, Xian;Xia, Hong;Hu, Xizhou;Xu, Zhimin;Hu, Xizhou

作者机构：

关键词： polymer monolith microextraction (PMME); determination; ligustrazine; rat serum

期刊名称：ACTA CHROMATOGRAPHICA （ 影响因子：1.418； 五年影响因子：0.936 ）

ISSN： 1233-2356

年卷期： 2021 年 33 卷 3 期

页码：

收录情况： SCI

摘要： This study focused on developing an effective and environmentally friendly method to measure ligustrazine in rat serum by using polymer monolith micro-extraction (PMME) technique. A poly (methacrylic acid-ethylene glycol dimethacrylate) material was used to extract ligustrazine through hydrophobic and ion-exchange interaction. Qualitative and quantitative analysis was performed by a liquid chromatography and tandem mass spectrometry. After optimization of several PMME conditions, the developed method exhibited excellent extraction performance to the ligustrazine. Good linearity was acquired ranging from 10 to 2,000 ng mL(-1), and the limit of detection of the proposed method was 0.14 ng mL(-1). The recoveries measured by spiking three different concentrations in rat serum ranged from 82.6 to 95.3%, and excellent precision was found with relative standard deviations (RSDs) less than 8.3% for intra-day and 9.7% for inter-day, respectively. At last, the applicability of the method was further confirmed through continuous monitoring of ligustrazine in rat serum after dosing of ligustrazine tablets to rats.

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