Effect of ammonia on the immune response of mud crab (Scylla paramamosain) and its susceptibility to mud crab reovirus

文献类型： 外文期刊

第一作者： Cheng, Chang-Hong

作者： Cheng, Chang-Hong;Ma, Hong-Ling;Deng, Yi-Qin;Feng, Juan;Jie, Yu-Kun;Guo, Zhi-Xun

作者机构：

关键词： Scylla paramamosain; MCRV infection; Ammonia exposure; Oxidative stress

期刊名称：ISRAELI JOURNAL OF AQUACULTURE-BAMIDGEH （ 影响因子：0.275； 五年影响因子：0.43 ）

ISSN： 0792-156X

年卷期： 2020 年 72 卷

页码：

收录情况： SCI

摘要： Ammonia is one of the major environmental pollutants that affect the growth and physiological functions of organisms. In the present study, the effects of ammonia on the immune response and pathogen resistance of mud crab reovirus (MCRV) in mud crab were investigated. Mud crab were exposed to four different ammonia concentrations (0, 2.5, 5 and 10 mg L-1 ammonia-N) for 7 d. The result showed that aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity significantly increased after 5 and 10 mg L-1 ammonia exposure. The hepatopancreas superoxide dismutase (SOD), catalase (CAT), and total antioxidative capacity (T-AOC) in ammonia-N group were significantly lower than those in the control group, while the levels of malondialdehyde (MDA) were significantly higher than those in the control group. Significant reductions in total hemocyte counts (THC) were observed after ammonia exposure. After 7d ammonia exposure, mud crabs were injected 100 mu L MCRV at 10(5) copies/g body weight. The mortality of mud crabs in ammonia-N group were significantly higher than those in the control group. All these results suggested that ammonia in water caused a depression in the immune response, and increased susceptibility to MCRV infection.

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