Whole-Proteome Differential Screening Identifies Novel Vaccine Candidates for Schistosomiasis japonica

文献类型： 外文期刊

第一作者： Wu, Hannah W.

作者： Wu, Hannah W.;Park, Sangshin;Pond-Tor, Sunthorn;Stuart, Ron;Zhou, Sha;Hong, Yang;Ruiz, Amanda E.;Acosta, Luz;Friedman, Jennifer F.;Kurtis, Jonathan D.;Wu, Hannah W.;Park, Sangshin;Friedman, Jennifer F.;Park, Sangshin;Zhou, Sha;Hong, Yang;Acosta, Luz;Jarilla, Blanca;Jiz, Mario;Kurtis, Jonathan D.

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关键词： Schistosoma japonicum; schistosomiasis; proteome; cohort; differential screening; vaccine

期刊名称：JOURNAL OF INFECTIOUS DISEASES （ 影响因子：5.022； 五年影响因子：5.057 ）

ISSN： 0022-1899

年卷期： 2021 年 223 卷 7 期

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收录情况： SCI

摘要： Schistosomiasis remains a leading cause of chronic morbidity in endemic regions despite decades of widespread mass chemotherapy with praziquantel. Using our whole proteome differential screening approach, and plasma and epidemiologic data from a longitudinal cohort of individuals living in a Schistosoma japonicum-endemic region of the Philippines, we interrogated the parasite proteome to identify novel vaccine candidates for Schistosoma japonicum. We identified 16 parasite genes which encoded proteins that were recognized by immunoglobulin G or immunoglobulin E antibodies in the plasma of individuals who had developed resistance to reinfection, but were not recognized by antibodies in the plasma of individuals who remained susceptible to reinfection. Antibody levels to Sj6-8 and Sj4-1 measured in the entire cohort (N = 505) 1 month after praziquantel treatment were associated with significantly decreased risk of reinfection and lower intensity of reinfection over 18 months of follow-up.

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