A novel plasmid from Aerococcus urinaeequi of porcine origin co-harboring the tetracycline resistance genes tet(58) and tet(61)

文献类型： 外文期刊

第一作者： Yang, Qin

作者： Yang, Qin;Zhu, Yao;Wang, Lingli;Liu, Wenyu;Yang, Wenlin;Luan, Tian;Liu, Siguo;Zhang, Wanjiang;Schwarz, Stefan

作者机构：

关键词： Plasmid; Tetracycline resistance; tet(61)-tet(58); Aerococcus urinaeequi

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.03； 五年影响因子：2.923 ）

ISSN： 0378-1135

年卷期： 2021 年 257 卷

页码：

收录情况： SCI

摘要： Tetracyclines are the broad-spectrum agents used in veterinary medicine and food animal production. Known mechanisms of tetracycline resistance include ribosome protection, active efflux and enzymatic inactivation. However, the presence of two different tet genes conferring different resistance mechanisms on the same plasmid has rarely been reported. In this study, we identified the tandem tetracycline resistance genes tet(61)-tet(58) on the novel plasmid pT4303. These tet genes were identified for the first time in Aerococcus urinaeequi. Reduced susceptibility to doxycycline was observed in S. aureus RN4220 harboring tet(61) when an extra tet(58) was expressed. Plasmid pT4303 was electrotransformed into S. aureus RN4220, E. faecalis JH2- 2, S. suis BAA and E. coli DH5 alpha and conferred tetracycline resistance (MIC >= 16) in both Gram-positive and Gram-negative bacteria, assuming that it might serve as a vehicle for the dissemination of the tetracycline resistance genes tet(61) and tet (58).

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