Molecular characterization and functional analysis of duck CCCH-type zinc finger antiviral protein (ZAP)
文献类型： 外文期刊
第一作者： Zhang, Rongrong
作者： Zhang, Rongrong;He, Yan;Wen, Guoyuan;Luo, Qingping;Zhang, Tengfei;Lu, Qin;Shao, Huabin;Zhang, Rongrong;He, Yan;Wen, Guoyuan;Luo, Qingping;Zhang, Tengfei;Lu, Qin;Shao, Huabin;Zhang, Rongrong;Zhu, Xinyu;Liu, Shudan;Xiao, Shaobo;Fang, Liurong
作者机构：
关键词： Duck; ZAP; Interferon-beta; DTMUV
期刊名称：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS （ 影响因子：2.985； 五年影响因子：2.75 ）
ISSN： 0006-291X
年卷期： 2021 年 561 卷
页码：
收录情况： SCI
摘要： This is the first study to clone duck CCCH-type zinc finger antiviral protein (duZAP) from Jingjiang duck (Anas platyrhynchos). Full-length duZAP cDNA was 2154 bp and encoded a 717-amino acid polypeptide containing four highly conserved CCCH-type finger motifs, a WWE domain and a poly (ADP-ribose) polymerase (PARP) domain. duZAP was expressed in multiple duck tissues, with the highest mRNA expression in the spleen. Overexpression of duZAP in duck embryo fibroblast cells (DEFs) led to activation of the transcription factors IRF1 and NF-kappa B, and induction of IFN-beta. Analysis of deletion mutants revealed that both the WWE and PARP domains of duZAP were essential for activating the IFN-beta promoter. Knockdown of duZAP in DEFs significantly reduced poly (I:C)- and duck Tembusu virus (DTMUV)induced IFN-beta activation. Our findings further the understanding of the role of duZAP in the duck innate immune response. (C) 2021 Elsevier Inc. All rights reserved.
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