Two new dipimprinine alkaloids from soil-derived Streptomyces sp. 44414B

文献类型: 外文期刊

第一作者: Liu, Manli

作者: Liu, Manli;Wan, Zhongyi;Liu, Fang;Wu, Zhaoyuan;Zhang, Yanni;Wang, Kaimei;Fang, Wei;Yang, Sumei;Yang, Xiliang

作者机构:

期刊名称:JOURNAL OF ANTIBIOTICS ( 影响因子:2.668; 五年影响因子:2.301 )

ISSN: 0021-8820

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收录情况: SCI

摘要: Two new dipimprinine alkaloids dipimprinine E (1) and dipimprinine F (2) were isolated from Streptomyces sp. 44414B. The structure was elucidated by extensive spectroscopic analysis, including ESI-MS, HR-MS, and 1D and 2D NMR experiments. Dipimprinines F (2) showed cytotoxic activities against three tumor cell lines, including A-875, Hep G2, and H-460, with IC50 values of 26.4, 0.5, and 9.0 mu g ml(-1), respectively.

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