Two new dipimprinine alkaloids from soil-derived Streptomyces sp. 44414B

文献类型： 外文期刊

第一作者： Liu, Manli

作者： Liu, Manli;Wan, Zhongyi;Liu, Fang;Wu, Zhaoyuan;Zhang, Yanni;Wang, Kaimei;Fang, Wei;Yang, Sumei;Yang, Xiliang

作者机构：

期刊名称：JOURNAL OF ANTIBIOTICS （ 影响因子：2.668； 五年影响因子：2.301 ）

ISSN： 0021-8820

年卷期：

页码：

收录情况： SCI

摘要： Two new dipimprinine alkaloids dipimprinine E (1) and dipimprinine F (2) were isolated from Streptomyces sp. 44414B. The structure was elucidated by extensive spectroscopic analysis, including ESI-MS, HR-MS, and 1D and 2D NMR experiments. Dipimprinines F (2) showed cytotoxic activities against three tumor cell lines, including A-875, Hep G2, and H-460, with IC50 values of 26.4, 0.5, and 9.0 mu g ml(-1), respectively.

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