J-Aggregation induced NIR-II fluorescence: an aza-BODIPY luminogen for efficient phototheranostics

文献类型： 外文期刊

第一作者： Yang, Na

作者： Yang, Na;Liu, Chang;Yao, Lang;Yu, Cong;Yang, Na;Song, Shuang;Akhtar, Mahmood Hassan;Liu, Chang;Yao, Lang;Yu, Jiayuan;He, Di;Yu, Cong;Li, Qianxue

作者机构：

期刊名称：JOURNAL OF MATERIALS CHEMISTRY B （ 影响因子：7.0； 五年影响因子：6.5 ）

ISSN： 2050-750X

年卷期： 2023 年 11 卷 40 期

页码：

收录情况： SCI

摘要： The development of organic dyes with emission peaks in the second near-infrared window (NIR-II 1000-1700 nm) is highly desirable for in vivo imaging and imaging-guided phototheranostics. However, the lack of appropriate molecular frameworks and the challenges associated with complex synthesis critically hinder the development of new candidate fluorophores. J-Aggregation is considered as a smart and straightforward way to construct such a therapeutic agent with NIR-II fluorescence imaging properties. Here, we present the design and synthesis of an aza-BODIPY probe (TA). Upon encapsulation within the amphiphilic polymer DSPEG-PEG2000-NH2, TA underwent self-assembly and formed J-aggregates (TAJ NPs), which showed emission at 1020 nm. High spatial resolution and adequate signal-to-noise ratio of the TAJ NPs are demonstrated for noninvasive bioimaging of the vasculature, lymph nodes and bones of mice in the NIR-II region. Moreover, the TAJ NPs exhibited good tumor enrichment efficiency with reduced liver accumulation and significant imaging-guided phototherapy performance against lung cancer cells. Taken together, this work not only introduces a new NIR-II imaging and phototheranostic agent based on J-aggregates, but also provides insight into the development of versatile organic dyes for future clinical implementation. NIR-II emissive J-aggregates of Aza-BODIPY for imaging-guided tumor therapy.

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